A 45-year-old patient with a life-threatening multidrug-resistant skull infection has achieved complete cure following bacteriophage therapy, marking a significant clinical milestone in treating infections that defy conventional antibiotics. The patient’s frontal bone infection, caused by Pseudomonas aeruginosa, persisted for 18 months despite treatment with six different antibiotics, including colistin and ceftazidime-avibactam. Dr. Aurore Denis and colleagues at the University Hospital of Rennes administered a targeted bacteriophage cocktail directly to multiple infection sites, resulting in complete bacterial eradication. The patient has remained infection-free for 12 months following treatment with no reported adverse effects. This case, published in the International Journal of Infectious Diseases, demonstrates how precision viral therapy can overcome bacterial resistance mechanisms that render conventional antimicrobials ineffective, offering renewed hope for patients with intractable infections.
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