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GMJ News > GMJ Briefs > Announcement: Skeletal muscle’s dual role: Why inactivity silences critical body signaling

Announcement: Skeletal muscle’s dual role: Why inactivity silences critical body signaling

GMJ
Last updated: 09/08/2026 19:29
By
Prof. Giorgi Pkhakadze
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Illustration of contracting muscle releasing myokines into circulation
Skeletal muscle operates in two distinct biochemical modes: active signaling and metabolic silence. Inactive muscle disengages from whole-body communication, raising chronic inflammation independent of weight status. — Photo by Tima Miroshnichenko on Pexels (Pexels License)
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1 min read|50 words

Skeletal muscle doesn't just build strength—it's a signaling organ. When muscles contract, they release myokines that regulate inflammation, metabolism, and stress responses. When muscles remain inactive, that signaling shuts down. Regular movement activates this protective communication, independent of weight loss.

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GMJ Brief · Announcement

📰 Read the full article: Skeletal muscle’s dual role: Why inactivity silences critical body signaling →

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ByProf. Giorgi Pkhakadze
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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

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