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GMJ News > GMJ Briefs > Deep in Your Brain Lies a Master Clock That Controls Your Entire Day

Deep in Your Brain Lies a Master Clock That Controls Your Entire Day

GMJ
Last updated: 04/10/2026 19:26
By
Prof. Giorgi Pkhakadze, MD, MPH, PhD
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1 Min Read
Illustration of the suprachiasmatic nucleus in the hypothalamus and circadian timing pathways
The suprachiasmatic nucleus in your brain acts as a master clock, orchestrating sleep, hunger, hormones, and energy across all organs via light exposure and circadian gene expression. Disruption through irregular light, late eating, and shift work impairs metabolic and mental health. — "The master circadian clock in the human brain" by Ian B Hickie, Sharon L Naismith, Rébecca Robillard, Elizabeth M Scott, and Daniel F Hermens is licensed under CC BY 3.0. To view a copy of this license, visit https://creativecommons.org/licenses/by/3.0/. (CC BY 3.0)
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1 min read|140 words

Your body is governed by an invisible timekeeper: the suprachiasmatic nucleus, a cluster of approximately 20,000 neurons nestled in the hypothalamus. This neural master clock orchestrates a 24-hour symphony of biological processes—from sleep and hunger to hormone release and mood regulation—synchronising virtually every organ system in your body.

Light exposure serves as the primary reset signal for this internal clock. When sunlight reaches your eyes in the early morning, it triggers a cascade of physiological changes: cortisol levels rise, body temperature climbs, and alertness sharpens. Conversely, as evening darkness falls, reduced light input signals melatonin production, initiating sleep. Understanding this light-dependent mechanism reveals why your biology at 8 AM differs profoundly from 8 PM, and why circadian misalignment through irregular light exposure or shift work can disrupt metabolic function, mood stability, and sleep quality.

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GMJ
ByProf. Giorgi Pkhakadze, MD, MPH, PhD
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MD, MPH, PhD. Editor-in-Chief, Georgian Medical Journal (GMJ). Professor and Head, School of Public Health, David Tvildiani Medical University (DTMU), Tbilisi, Georgia. Chair, Public Health Institute of Georgia (PHIG). President, Accréditation Sans Frontières (ASF), Paris. Secretary/Treasurer, UEMS Section of Public Health. WHO Consultant, Health and Migration, Geneva. Former Member, UN Secretary-General's Independent Accountability Panel for Every Woman, Every Child, Every Adolescent (IAP-EWEC, 2016–2021). ORCID: 0000-0001-7609-4515.

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