Announcement: The B-Vitamin Methylation Triad: How B12, Folate, and B6 Work Together in Cardiovascular and Neurological Health

Last updated: 07/08/2026 17:29

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B12, folate, and B6 form an integrated metabolic system supporting DNA synthesis, homocysteine regulation, and neurological function. Current RDA levels prevent deficiency but may not optimise function in individuals with elevated cardiovascular risk or malabsorption. — Photo by Andrey Khoviakov on Unsplash (Unsplash License)

B vitamins aren't isolated nutrients—they work as a tightly linked system. When B12, folate, and B6 function together, they drive one-carbon metabolism, regulate homocysteine, and support DNA synthesis. Learn why deficiency in any one can compromise the entire pathway.

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GMJ Brief · Announcement

📰 Read the full article: The B-Vitamin Methylation Triad: How B12, Folate, and B6 Work Together in Cardiovascular and Neurological Health →

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ByProf. Giorgi Pkhakadze, MD, MPH, PhD

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MD, MPH, PhD. Editor-in-Chief, Georgian Medical Journal (GMJ). Professor and Head, School of Public Health, David Tvildiani Medical University (DTMU), Tbilisi, Georgia. Chair, Public Health Institute of Georgia (PHIG). President, Accréditation Sans Frontières (ASF), Paris. Secretary/Treasurer, UEMS Section of Public Health. WHO Consultant, Health and Migration, Geneva. Former Member, UN Secretary-General's Independent Accountability Panel for Every Woman, Every Child, Every Adolescent (IAP-EWEC, 2016–2021). ORCID: 0000-0001-7609-4515.