Announcement: Vitamin D Thresholds Remain Contested Despite Large Clinical Trials

Last updated: 08/08/2026 19:30

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Five large randomised controlled trials involving over 100,000 participants found mostly null effects on hard clinical endpoints, prompting the Endocrine Society to revise its 2024 vitamin D sufficiency threshold back to 20 ng/mL—aligning with broader scientific consensus and challenging influencer claims of "optimal" higher levels. — Photo by Nataliya Vaitkevich on Pexels (Pexels License)

1 min read|62 words

The vitamin D threshold debate just got clearer. Five massive RCTs with 100,000+ participants found that higher vitamin D levels didn't prevent fractures, heart disease, or cancer in general populations. The Endocrine Society's 2024 update aligns on 20 ng/mL—not the 60 ng/mL influencers claim. Read why biochemical plausibility doesn't always match trial reality.

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GMJ Brief · Announcement

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ByProf. Giorgi Pkhakadze

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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

Announcement: Vitamin D Thresholds Remain Contested Despite Large Clinical Trials

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