A landmark systematic review published in Nutrients by researchers at Boston University School of Medicine has synthesized evidence linking vitamin D deficiency to a diverse range of acute and chronic conditions. The analysis, conducted by Charoenngam and Holick, reveals that inadequate vitamin D status compromises immune regulation and increases disease susceptibility across multiple organ systems.
The review identifies direct causative relationships in bone disorders—rickets in children and osteoporosis in adults—while documenting associations with autoimmune conditions including multiple sclerosis, type 1 diabetes, and inflammatory bowel disease. Notably, the researchers emphasize that disease relationships are bidirectional: deficiency can precipitate illness, while chronic disease can reduce vitamin D synthesis. The evidence underscores the importance of balanced sun exposure and dietary vitamin D sources in disease prevention.
Read the full article on GMJ Newsroom.
Was this article helpful?
