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GMJ News > GMJ Briefs > Key Finding: Brain preservation depends on where you store fat, not how much you weigh

Key Finding: Brain preservation depends on where you store fat, not how much you weigh

GMJ
Last updated: 03/08/2026 17:29
By
Prof. Giorgi Pkhakadze
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Illustration comparing visceral and subcutaneous fat distribution and their effects on brain volume
A 16-year study reveals that visceral fat accumulation—not total weight—predicts brain volume loss and cognitive decline. Glucose control, not cholesterol, mediates the effect. — Photo by cottonbro studio on Pexels (Pexels License)
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1 min read|33 words

86% of study participants were male—a critical limitation for understanding how visceral fat affects women's brain aging. Generalizability remains a key gap in metabolic neuroscience.

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GMJ Brief · Key Finding

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ByProf. Giorgi Pkhakadze
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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

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