Chronic graft-versus-host disease (cGVHD) emerges as a critical priority in post-transplant care, affecting the vast majority of allogeneic haematopoietic cell transplantation (HCT) survivors with variable organ involvement. A comprehensive Nature Reviews Disease Primers review consolidates current evidence on cGVHD epidemiology, pathophysiology, and management, providing clinicians with an integrated diagnostic framework that combines clinical assessment, histopathological findings, and specialized laboratory investigations.
The review highlights that effective management requires a multidisciplinary approach spanning immunosuppressive therapies, novel agents including JAK inhibitors, and tailored supportive care strategies. With skin and oral tissues affected in over 75% of cases, alongside significant involvement of eyes, gastrointestinal, pulmonary, and hepatic systems, coordinated care across specialties is essential. Notably, the analysis identifies quality-of-life outcomes and long-term survival as critical yet understudied dimensions of cGVHD care, signaling the need for enhanced follow-up infrastructure and patient-centered research initiatives.
Read the full article on GMJ Newsroom.
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