Tag: immunometabolism

Diagram of TCA cycle intermediates and their regulatory roles in cellular signalling, histone modification, and immune function
ExplainersNew StudiesPerspectivesResearch Digest

Mitochondrial metabolism reshapes immunity, stem cells, and tumour development

Mitochondrial TCA cycle intermediates function as master regulators of immune responses, stem cell fate, and tumour development. Supporting mitochondrial health…

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GMJ Perspectives Desk
Diagram of TCA cycle intermediates and their regulatory roles in immune and stem cell biology
ExplainersNew StudiesPerspectivesResearch Digest

Beyond Energy: How Mitochondrial Metabolites Control Immunity, Stem Cells, and Cancer Risk

Mitochondrial metabolites—acetyl-CoA, α-ketoglutarate, itaconate, succinate, and fumarate—function as master regulators of immune tolerance, stem cell fate, and tumor suppression, not…

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GMJ Perspectives Desk

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