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GMJ News > GMJ Briefs > Mapping the Brain’s Anxiety Circuit: New Path to Targeted Treatments

Mapping the Brain’s Anxiety Circuit: New Path to Targeted Treatments

GMJ
Last updated: 15/06/2026 04:17
By
Prof. Giorgi Pkhakadze
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1 Min Read
Scientific illustration of amygdala brain circuits involved in anxiety processing
Researchers successfully reversed anxiety in mice by targeting a specific group of amygdala neurons. The breakthrough identifies a promising new target for developing more precise anxiety treatments. — Photo: Robina Weermeijer / Pexels
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1 min read|128 words

Neuroscientists have identified a previously unknown population of neurons within the amygdala that directly control anxiety and social behavior, opening new avenues for precision medicine in psychiatric care. In experimental studies, researchers successfully reversed anxiety symptoms and social deficits in mice by restoring normal activity patterns within this specific neural circuit.

The discovery represents a significant advance in understanding the neurobiological basis of anxiety disorders, which affect millions of people worldwide. By pinpointing the exact neurons responsible for anxiety responses, researchers have identified a potential therapeutic target that could lead to more effective treatments with improved side effect profiles compared to current pharmacological approaches.

This circuit-based understanding of anxiety may fundamentally reshape how clinicians approach anxiety disorder treatment in the future. Read the full article on GMJ Newsroom.

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ByProf. Giorgi Pkhakadze
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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

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