New clinical evidence validates what millions of women experience during perimenopause: measurable cognitive decline affecting memory, concentration, and executive function. Research published in peer-reviewed journals demonstrates that brain fog during the menopausal transition stems from measurable biological changes, not psychological factors as previously assumed. Standardized neuropsychological testing shows significant decreases in verbal memory, working memory, and processing speed compared to premenopausal baselines, with deficits peaking during late perimenopause when hormone fluctuations are most pronounced. Neuroimaging studies reveal reduced brain connectivity in regions critical for memory and executive function during periods of low estrogen. These findings have substantial implications for clinical practice, workplace accommodations, and treatment strategies. Both hormonal and non-hormonal interventions show promise in managing symptoms and preserving cognitive function during this transitional period. Read the full article on GMJ Newsroom.
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