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GMJ News > GMJ Briefs > Key Finding: PROTEUS Trial Shows Promise for Perioperative Prostate Cancer Therapy

Key Finding: PROTEUS Trial Shows Promise for Perioperative Prostate Cancer Therapy

GMJ
Last updated: 02/10/2026 19:26
By
Prof. Giorgi Pkhakadze, MD, MPH, PhD
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Medical illustration of prostate cancer treatment with perioperative androgen-deprivation therapy and apalutamide combined approach
A landmark PROTEUS trial published in Nature Medicine (June 2026) demonstrates that combining perioperative androgen-deprivation therapy with apalutamide offers a new treatment pathway for high-risk, localized prostate cancer, potentially reducing biochemical recurrence when administered before radical prostatectomy. — Photo by Logan Gutierrez on Unsplash (Unsplash License)
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Perioperative medical therapy now part of curative-intent prostate cancer surgery: PROTEUS trial demonstrates that combining ADT + apalutamide before radical prostatectomy reduces recurrence risk in high-risk disease. Game-changer for urology.

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GMJ Brief · Key Finding

📰 Read the full article: PROTEUS Trial Shows Promise for Perioperative Prostate Cancer Therapy →

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ByProf. Giorgi Pkhakadze, MD, MPH, PhD
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MD, MPH, PhD. Editor-in-Chief, Georgian Medical Journal (GMJ). Professor and Head, School of Public Health, David Tvildiani Medical University (DTMU), Tbilisi, Georgia. Chair, Public Health Institute of Georgia (PHIG). President, Accréditation Sans Frontières (ASF), Paris. Secretary/Treasurer, UEMS Section of Public Health. WHO Consultant, Health and Migration, Geneva. Former Member, UN Secretary-General's Independent Accountability Panel for Every Woman, Every Child, Every Adolescent (IAP-EWEC, 2016–2021). ORCID: 0000-0001-7609-4515.

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