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GMJ News > GMJ Briefs > Key Finding: Higher-dose primaquine halves P. vivax recurrence in Indonesia, but safety trade-offs emerge

Key Finding: Higher-dose primaquine halves P. vivax recurrence in Indonesia, but safety trade-offs emerge

GMJ
Last updated: 05/10/2026 03:26
By
Prof. Giorgi Pkhakadze, MD, MPH, PhD
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Infographic comparing primaquine dosing efficacy and safety trade-offs in P. vivax malaria treatment
A meta-analysis of Indonesian data shows that doubling the primaquine dose from 3.5 mg/kg to 7 mg/kg halves P. vivax recurrence rates at 6 months, but increases gastrointestinal and haemolytic side effects. Rapid G6PD screening becomes mandatory before deploying higher-dose regimens safely. — Photo by www.kaboompics.com on Pexels (Pexels License)
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1 min read|36 words

50% recurrence reduction with 7 mg/kg primaquine vs standard 3.5 mg/kg in P. vivax treatment—if G6PD screening is done first. Major implications for Indonesia's malaria elimination drive.

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GMJ Brief · Key Finding

📰 Read the full article: Higher-dose primaquine halves P. vivax recurrence in Indonesia, but safety trade-offs emerge →

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ByProf. Giorgi Pkhakadze, MD, MPH, PhD
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MD, MPH, PhD. Editor-in-Chief, Georgian Medical Journal (GMJ). Professor and Head, School of Public Health, David Tvildiani Medical University (DTMU), Tbilisi, Georgia. Chair, Public Health Institute of Georgia (PHIG). President, Accréditation Sans Frontières (ASF), Paris. Secretary/Treasurer, UEMS Section of Public Health. WHO Consultant, Health and Migration, Geneva. Former Member, UN Secretary-General's Independent Accountability Panel for Every Woman, Every Child, Every Adolescent (IAP-EWEC, 2016–2021). ORCID: 0000-0001-7609-4515.

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