A preliminary study has identified a potentially significant mechanism by which melatonin supplementation may safeguard night shift workers from health risks associated with disrupted circadian rhythms. Researchers found that the hormone enhances cellular DNA repair processes, which typically deteriorate when the body’s internal clock is disrupted by overnight work schedules.
Approximately 15 million Americans work night shifts regularly, exposing them to increased risks of cancer, cardiovascular disease, and metabolic disorders. The World Health Organization has classified circadian-disrupting shift work as a probable carcinogen. This new research suggests that melatonin’s dual role as both an antioxidant and regulator of DNA repair enzymes could help restore some of the cellular maintenance capacity lost during shift work, potentially informing new workplace health strategies.
While the findings are encouraging, researchers emphasize that larger clinical trials are needed to validate these preliminary results and establish optimal dosing protocols.
Read the full article on GMJ Newsroom.
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