Prof. Giorgi Pkhakadze, MD, MPH, PhD
NEJM Retracts Landmark Avacopan Vasculitis Trial After Data Integrity Concerns
The New England Journal of Medicine has retracted a landmark 2021 trial on avacopan for ANCA-associated vasculitis following identification of…
Automated Genomic Reanalysis Tool Offers Rare Disease Diagnoses at Scale and Low Cost
Researchers have developed Talos, an open-source tool for automating reanalysis of genomic data from patients with rare genetic diseases, enabling…
Correction Published for ABBV-706 Phase 1 Trial in Small Cell Lung Cancer and Solid Tumors
Nature Medicine has published an author correction to the ABBV-706 phase 1 trial, a SEZ6-targeting antibody-drug conjugate for advanced small…
Creatine as a Depression Treatment: What the Evidence Shows
A systematic review of five randomized clinical trials found mixed evidence for creatine as an adjunctive depression treatment: two trials…
New mapping of noma disease across Nigeria reveals scale of neglected tropical disease burden
New epidemiological mapping of noma disease across Nigeria reveals the extent of a neglected tropical infection that kills 80–90% of…
Novel T-cell therapy targets three tumor proteins in aggressive pediatric brain cancers, shows early survival promise
Engineered T-cell immunotherapy targeting three tumor proteins has produced early survival gains in children with diffuse intrinsic pontine glioma and…
Lab-Grown Retinal Cells Restore Vision in Mice, Opening Path to Human Eye Therapies
Researchers at Duke University have successfully grown retinal blood vessel cells from stem cells and demonstrated their ability to restore…
When Scale Outpaces Vigilance: The GLP-1 Drugs and the Wernicke Signal
A new study links rare cases of Wernicke encephalopathy to GLP-1 weight-loss drugs. The real lesson: rapid global adoption demands…