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GMJ News > GMJ Briefs > Early Detection of Brain Chemistry Imbalance: Why Symptoms Precede Structural Disease

Early Detection of Brain Chemistry Imbalance: Why Symptoms Precede Structural Disease

GMJ
Last updated: 06/08/2026 15:30
By
Prof. Giorgi Pkhakadze
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Diagram of neurotransmitter molecules and brain cell communication
Neurotransmitters—dopamine, serotonin, acetylcholine, and nine others—regulate mood, sleep, focus, and motivation through chemical signalling between brain cells. When this signalling becomes dysregulated, functional symptoms emerge before structural brain disease develops. — Photo by SHVETS production on Pexels (Pexels License)
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1 min read|117 words

Recent neuroscience research confirms that twelve major neurotransmitters regulate distinct functions across mood, cognition, sleep, and stress resilience. Critically, dysregulation of these neurochemical systems produces functional symptoms—including mood changes, sleep disruption, and cognitive fog—long before structural brain pathology becomes apparent. This finding has profound implications for mental health care: it suggests that early intervention targeting neurotransmitter balance may prevent progression to more severe neurological conditions. The balance between excitatory signals (glutamate) and inhibitory signals (GABA) is particularly vital to neural stability. When this equilibrium is maintained, mental health and cognitive performance thrive. When dysregulated, functional impairment emerges. Understanding this timeline allows clinicians to identify at-risk individuals sooner and implement evidence-based interventions to restore neurochemical homeostasis.

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ByProf. Giorgi Pkhakadze
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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

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