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GMJ News > GMJ Briefs > Key Finding: How Synaptic Signalling Powers Every Thought, Mood, and Decision

Key Finding: How Synaptic Signalling Powers Every Thought, Mood, and Decision

GMJ
Last updated: 04/10/2026 19:26
By
Prof. Giorgi Pkhakadze, MD, MPH, PhD
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Diagram showing synaptic transmission: electrical impulse, neurotransmitter release, receptor binding, and reuptake mechanism
Every thought, mood, and decision emerges from synaptic signalling—a process where seven major neurotransmitter systems work in concert across trillions of neural connections. Understanding this chemistry is reshaping treatment of psychiatric and neurological disease. — "Neuronal synapse, artwork" is marked with CC0 1.0. To view the terms, visit https://creativecommons.org/publicdomain/zero/1.0/. (CC0 1.0 (Public Domain))
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1 min read|34 words

Trillions of synaptic signals fire per second across the human brain, coordinated by seven major neurotransmitter systems. Understanding this multiplexed chemistry is revolutionising psychiatric and neurological treatment.

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GMJ Brief · Key Finding

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ByProf. Giorgi Pkhakadze, MD, MPH, PhD
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MD, MPH, PhD. Editor-in-Chief, Georgian Medical Journal (GMJ). Professor and Head, School of Public Health, David Tvildiani Medical University (DTMU), Tbilisi, Georgia. Chair, Public Health Institute of Georgia (PHIG). President, Accréditation Sans Frontières (ASF), Paris. Secretary/Treasurer, UEMS Section of Public Health. WHO Consultant, Health and Migration, Geneva. Former Member, UN Secretary-General's Independent Accountability Panel for Every Woman, Every Child, Every Adolescent (IAP-EWEC, 2016–2021). ORCID: 0000-0001-7609-4515.

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