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GMJ News > GMJ Briefs > Key Finding: How the brain controls inflammation: The vagus nerve’s unexpected role in immune regulation

Key Finding: How the brain controls inflammation: The vagus nerve’s unexpected role in immune regulation

GMJ
Last updated: 11/08/2026 03:30
By
Prof. Giorgi Pkhakadze
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Diagram of the inflammatory reflex pathway showing vagus nerve signalling from brainstem to spleen, triggering immune modulation
The brain controls inflammation through an electrical circuit called the inflammatory reflex, mediated by the vagus nerve. Clinical trials show vagus nerve stimulation reduces inflammatory markers in rheumatoid arthritis without immunosuppressive drugs. — "Gut-brain axis overview" by Chao Yin-Xia, Gulam Muhammad Yaaseen, Chia Nicholas Shyh Jenn, Feng Lei, Rotzschke Olaf, Tan Eng-King is licensed under CC BY 4.0. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. (CC BY 4.0)
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1 min read|30 words

In animal models, vagus nerve stimulation increased immune-modulating noradrenaline in the spleen within MINUTES—showing how fast the nervous system can regulate inflammation.

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ByProf. Giorgi Pkhakadze
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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

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