Takeaway: Aerobic Exercise Reverses Age-Related Hippocampal Shrinkage in Older Adults

Last updated: 16/08/2026 09:30

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A 12-month aerobic exercise trial published in PNAS reversed age-related hippocampal shrinkage in older adults, with participants gaining 2% in brain volume. New mechanistic evidence reveals how exercise restores mitochondrial health and reduces neuroinflammation in the aging hippocampus. — Photo by Andrea Piacquadio on Pexels (Pexels License)

1 min read|51 words

Why aerobic exercise is the gold standard for brain aging: 1) Replicated human neuroimaging evidence shows 2% hippocampal volume expansion. 2) Spatial memory improves in parallel with brain structure gains. 3) Mechanistic animal studies reveal exercise restores mitochondrial health and reduces neuroinflammation. No supplement matches this evidence base.

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ByProf. Giorgi Pkhakadze, MD, MPH, PhD

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MD, MPH, PhD. Editor-in-Chief, Georgian Medical Journal (GMJ). Professor and Head, School of Public Health, David Tvildiani Medical University (DTMU), Tbilisi, Georgia. Chair, Public Health Institute of Georgia (PHIG). President, Accréditation Sans Frontières (ASF), Paris. Secretary/Treasurer, UEMS Section of Public Health. WHO Consultant, Health and Migration, Geneva. Former Member, UN Secretary-General's Independent Accountability Panel for Every Woman, Every Child, Every Adolescent (IAP-EWEC, 2016–2021). ORCID: 0000-0001-7609-4515.