1 min read|90 words
Phenibut (β-phenyl-GABA) is a synthetic GABA-B agonist and voltage-dependent calcium channel blocker developed in the Soviet Union (1960s) as an anxiolytic [1]. It is a prescription drug in Russia/Eastern Europe but sold as a 'nootropic supplement' in the US/EU. Phenibut causes physical dependence rapidly (within 1–2 weeks of daily use) with a SEVERE withdrawal syndrome (anxiety, insomnia, psychosis, seizures) that can require ICU-level care. Poison control calls for phenibut have increased >900% since 2015. FDA has warned it is not a legitimate dietary ingredient [1].
Category: Dangerous/banned
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