Pig Liver Xenografts Show Promise in Early Human Trials for Liver Failure
Gene-edited pig liver xenografts successfully functioned in extracorporeal cross-circulation with human blood, generating the first comprehensive immune, coagulation, and metabolic…
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NHS Delayed Discharges Cost Reaches £2.7bn Annually, Threatening Government’s 2029 Corridor Care Target
Delayed hospital discharges in England now cost the NHS £2.7 billion annually, a 7.5% increase, with 12,978 patients occupying beds…
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Tailored drug combinations show promise against treatment-resistant melanoma in preclinical study
Researchers at MD Anderson Cancer Center have developed a strategy to match drug combinations to tumor biomarkers in treatment-resistant melanoma,…
University of Queensland Drug Targets Immune Receptor, Offering Hope for Motor Neuron Disease
Researchers at the University of Queensland have developed a novel drug that activates a previously difficult-to-target immune receptor, a breakthrough…
Blood test with circular RNA markers predicts Alzheimer’s disease years before symptoms emerge
A blood test measuring 34 circular RNA markers predicts Alzheimer's disease progression with 92% accuracy, outperforming current protein biomarkers and…
Innate Immune Strength Paradoxically Linked to Worse Flu Symptoms in Controlled Challenge Study
A controlled human influenza challenge study in Nature Medicine reveals that heightened innate immune cell responsiveness paradoxically correlates with increased…
Neurotensin Receptor 2 Activation Shows Promise in Preventing Heart Failure Progression
Activation of neurotensin receptor 2 in preclinical models significantly reduced pathological changes in heart tissue, suggesting a novel therapeutic target…
Cerebellar Cell Discovery Reshapes Understanding of Movement Disorders
Researchers have discovered that two key cerebellar cell types—long assumed to work in tandem—behave independently in many cases, challenging foundational…
Half of kidney transplant candidates never begin evaluation, US study reveals
A national cohort study reveals that 50% of Americans referred for kidney transplant evaluation never initiate the process, and only…
Would Hunters Accept a Lyme Disease Vaccine? New Research Reveals Hesitation Among High-Risk Groups
As tick populations reach decade-high levels, new research reveals vaccine hesitancy among hunters and outdoor workers despite documented occupational exposure…