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GMJ News > GMJ Briefs > 2 Kilograms: The Weight Loss Advantage of Semaglutide in Diabetes Treatment

2 Kilograms: The Weight Loss Advantage of Semaglutide in Diabetes Treatment

GMJ
Last updated: 02/07/2026 12:25
By
Prof. Giorgi Pkhakadze
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Chart comparing semaglutide and dulaglutide effectiveness in type 2 diabetes treatment
Large UK study shows weekly semaglutide provides superior blood sugar control and weight loss compared to dulaglutide in type 2 diabetes patients. Real-world evidence supports preferential use in clinical practice. — Photo by Haberdoedas Photography on Pexels (Pexels License)
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1 min read|141 words

Among the most significant findings from a comprehensive UK diabetes study is the quantifiable weight loss advantage associated with weekly semaglutide compared to dulaglutide. Over a 12-month period, patients treated with semaglutide achieved an additional 2.06 kg of weight reduction—a clinically meaningful difference that, when combined with other metabolic benefits, contributes substantially to overall disease management and cardiovascular health outcomes.

Beyond weight loss, the study documented that semaglutide users also achieved 0.20% greater HbA1c reduction, indicating superior blood sugar control. These findings emerged from analysis of 6,103 adults in UK primary care, with 3,227 receiving semaglutide and 2,876 receiving dulaglutide between 2018 and 2022.

Both medications demonstrated comparable safety profiles, suggesting that the metabolic advantages of semaglutide were achieved without increased adverse event burden. This data supports clinicians in making evidence-based treatment selections for their patients with type 2 diabetes.

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📰 Read the full article: Weekly semaglutide outperforms dulaglutide for diabetes control in UK primary care study →

Related reference
  • Type 2 Diabetes · Condition
  • Semaglutide · Drug
  • Dulaglutide · Drug
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ByProf. Giorgi Pkhakadze
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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

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