A comprehensive pooled analysis of 10 prospective cohort studies has quantified the relationship between daily coffee consumption and dementia incidence with striking precision. Among 450,000 community-dwelling adults tracked over an average of 11.5 years, those consuming 2 to 3 cups daily experienced a 35% reduction in dementia risk compared to non-drinkers. However, the protective effect diminished at higher intakes: consumption of 3 to 4 cups yielded 25% risk reduction, while 4 or more cups per day was associated with a 5% increase in risk. This dose-response relationship, published by Mazzoleni and colleagues, challenges one-dimensional dietary recommendations and highlights the importance of moderation. The findings remain observational, requiring caution in causal interpretation. Read the full article on GMJ Newsroom.
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