An enzyme called GSK-3β accelerates cellular aging in the brain and is overactive in Alzheimer's disease. Lithium, chemically similar to magnesium, can displace magnesium at the enzyme's active site and slow its activity. Epidemiological research suggests trace-dose lithium (around 1 mg daily) may offer neuroprotective benefits, but human clinical evidence remains limited. — Photo by Shawn Day on Unsplash (Unsplash License)
MD, MPH, PhD. Editor-in-Chief, Georgian Medical Journal (GMJ). Professor and Head, School of Public Health, David Tvildiani Medical University (DTMU), Tbilisi, Georgia. Chair, Public Health Institute of Georgia (PHIG). President, Accréditation Sans Frontières (ASF), Paris. Secretary/Treasurer, UEMS Section of Public Health. WHO Consultant, Health and Migration, Geneva. Former Member, UN Secretary-General's Independent Accountability Panel for Every Woman, Every Child, Every Adolescent (IAP-EWEC, 2016–2021). ORCID: 0000-0001-7609-4515.
