Recent meta-analysis examining magnesium supplementation efficacy has identified at least eight different salt forms demonstrating cognitive benefits in human clinical trials. Magnesium oxide leads with six studies, followed by glycinate and citrate with five and four studies respectively, while threonate—heavily marketed for neurological function—shows evidence in only two human trials.
This distribution challenges the supplement industry’s narrative that specialized salt forms provide superior outcomes for specific tissues or conditions. Researchers emphasize that bioavailability and adequate dosing matter more than the specific chemical compound selected. The findings underscore a critical gap between marketing claims and scientific evidence in the nutritional supplement marketplace.
These results have significant implications for clinical practice, consumer education, and regulatory oversight of supplement advertising claims.
Read the full article on GMJ Newsroom.
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