Bones are metabolic organs, not merely structural tissue. Mechanical loading triggers osteocalcin release, which improves insulin sensitivity and glucose regulation through a bone–pancreas–muscle feedback loop—linking skeletal mechanics to systemic metabolic health. — Photo by cottonbro studio on Pexels (Pexels License)
Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.
