New research quantifies a striking difference in neural capacity between physically active and sedentary aging populations. Master athletes retain motoneuron excitability levels 2.4 times higher than sedentary older adults, demonstrating that age itself does not drive neural decline. The comparative analysis reveals a clear progression: master athletes maintained 92% persistent inward current capacity, nonsarcopenic older adults showed 68%, while sarcopenic individuals exhibited only 38%. These findings suggest that inactivity, rather than chronological age, is the primary driver of neural deterioration. The data underscore a critical clinical message: long-term engagement in resistance and high-intensity exercise preserves the nervous system’s capacity to signal and control muscle contraction, regardless of advancing years. This evidence supports preventive strategies prioritizing sustained physical activity throughout the lifespan.
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