A comprehensive meta-analysis of five studies encompassing 1,460 eyes has established compelling evidence for teleretinal screening’s diagnostic performance in detecting cytomegalovirus retinitis among people living with HIV. The analysis revealed a specificity rate of 97.73%, sensitivity of 87.11%, and overall diagnostic accuracy exceeding 95%.
These metrics are clinically significant: the high specificity means that positive screening results are highly reliable, reducing false positives that could lead to unnecessary interventions. The sensitivity level demonstrates the technology’s capacity to identify most cases of CMVR, particularly critical given the disease’s potential for rapid progression and vision loss.
The data, published in PLOS Global Public Health and conducted according to PRISMA diagnostic test accuracy guidelines, provides the first comprehensive evidence base supporting teleretinal screening’s role in HIV eye care delivery.
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