A comprehensive analysis of pharmacological interaction studies from 2015 to 2024 has identified a critical benchmark: vitamin C supplementation above 2,000 mg daily substantially increases the risk of clinically significant drug interactions. This threshold represents a turning point where vitamin C transitions from a generally safe nutrient to a potential medication antagonist. Anticoagulants face the highest risk category, followed by statins and chemotherapy agents. The dose-dependent relationship means that patients taking supplements within recommended dietary allowances—90 mg daily for adults—remain at minimal risk. However, the widespread availability of high-potency vitamin C products has made excessive supplementation common, often without patient awareness of medication conflicts. Spacing supplements from medications by 2 or more hours can reduce interaction severity, but pharmacist consultation remains essential. Read the full article on GMJ Newsroom.
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