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GMJ News > GMJ Briefs > Two-Dose Nasal Spray Shows Promise in Reversing Cognitive Aging Markers

Two-Dose Nasal Spray Shows Promise in Reversing Cognitive Aging Markers

GMJ
Last updated: 29/06/2026 09:07
By
Prof. Giorgi Pkhakadze
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1 Min Read
Laboratory researcher preparing nasal spray for brain aging study
Texas A&M researchers developed a nasal spray that reverses brain aging markers in preclinical studies. Just two doses improved memory and cognitive function for months by targeting inflammation. — Photo by Shawn Day on Unsplash (Unsplash License)
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1 min read|133 words

Researchers at Texas A&M University have developed an innovative nasal spray formulation that demonstrates the ability to reverse markers of brain aging in preclinical studies. The treatment, which targets neuroinflammatory pathways, showed sustained cognitive improvements lasting for months following just two doses. By delivering therapeutic compounds directly through olfactory pathways, the nasal spray bypasses the blood-brain barrier, reducing systemic side effects while achieving targeted brain tissue penetration. The study revealed measurable enhancements in memory formation and retention, alongside restoration of cellular energy production in regions critical for learning. These findings suggest that anti-inflammatory interventions may represent a promising therapeutic avenue for addressing age-related cognitive decline. While human clinical trials remain necessary, this research offers encouraging preliminary evidence for a novel approach to managing neurological aging. Read the full article on GMJ Newsroom.

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ByProf. Giorgi Pkhakadze
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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

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