NEJM Retracts Landmark Avacopan Vasculitis Trial After Data Integrity Concerns
The New England Journal of Medicine has retracted a landmark 2021 trial on avacopan for ANCA-associated vasculitis following identification of…
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Automated Genomic Reanalysis Tool Offers Rare Disease Diagnoses at Scale and Low Cost
Researchers have developed Talos, an open-source tool for automating reanalysis of genomic data from patients with rare genetic diseases, enabling…
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New R&D Ranking Reveals Sharp Disparities in Pharmaceutical Innovation Efficiency
A new evidence-based ranking of pharmaceutical companies reveals significant disparities in how efficiently firms convert R&D spending into drug approvals.…
New treatment approach offers hope for pre-eclampsia, a leading cause of maternal death
Pre-eclampsia causes more than 70,000 maternal deaths annually worldwide. Researchers are now investigating novel therapeutic approaches targeting placental dysfunction and…
Why Some Cancers Evade Chemotherapy: New Mechanism Identified
Researchers have identified a molecular mechanism that enables cancer cells to survive chemotherapy, revealing how 30–40% of treated tumors develop…
How Muscle Really Grows: Exercise Triggers Protein Synthesis, Not Just Microscopic Tears
Research now shows that muscle growth is driven primarily by elevated protein synthesis triggered by mechanical tension, not by microscopic…