Announcement: How Vitamin D Becomes Active: The Three-Organ Pathway Explained

Last updated: 09/08/2026 01:29

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Vitamin D activation involves a complex three-organ cascade requiring magnesium, iron, vitamin K2, zinc, and vitamin A as essential cofactors. Deficiency in any micronutrient can block this pathway despite adequate vitamin D intake. — Photo by Saul Rivera on Pexels (Pexels License)

1 min read|49 words

Vitamin D doesn't work alone. Its activation across skin, liver, and kidney requires magnesium, iron, vitamin K2, zinc, and vitamin A. Deficiency in ANY of these can block the entire pathway. Learn the complete 7-step cascade and why micronutrient synergy matters.

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GMJ Brief · Announcement

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ByProf. Giorgi Pkhakadze

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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.