Key Finding: How Vitamin D Becomes Active: The Three-Organ Pathway Explained

Last updated: 16/08/2026 01:29

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Vitamin D activation involves a complex three-organ cascade requiring magnesium, iron, vitamin K2, zinc, and vitamin A as essential cofactors. Deficiency in any micronutrient can block this pathway despite adequate vitamin D intake. — Photo by Saul Rivera on Pexels (Pexels License)

1 min read|29 words

7 steps convert sunlight into active hormone. But all 3 organ systems need cofactors—magnesium, iron, K2, zinc, vitamin A—or the chain breaks.

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GMJ Brief · Key Finding

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ByProf. Giorgi Pkhakadze

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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

Key Finding: How Vitamin D Becomes Active: The Three-Organ Pathway Explained

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