Prof. Giorgi Pkhakadze, MD, MPH, PhD
Why Every Vitamin Matters: A Clinical Guide to Deficiency and Function
Vitamins regulate fundamental biological processes, yet deficiency remains underrecognized in clinical practice. Understanding the specific functions and deficiency syndromes of…
Vitamin D as Endocrine Hormone: How a Single Molecule Orchestrates Immunity, Bone Health, and Gene Expression
Vitamin D functions as a steroid hormone controlling over 200 genes, not simply as a micronutrient. Once activated through hepatic…
Dietary Fiber Is Not Fixed: How Biology, Processing, and Measurement Shape Nutrition
Dietary fiber content varies dramatically by ripeness, growing conditions, cooking method, plant variety, and measurement protocol. An unripe banana contains…
Beyond the Powerhouse: Four Core Functions That Define Mitochondrial Health
Mitochondria are far more than the cell's powerhouse. They simultaneously manage ATP production, oxidative stress regulation, genetic integrity, and quality…
Semaglutide’s lean mass loss exceeds dietary norms — but resistance training may offset the effect
Semaglutide causes lean mass loss exceeding the 25% baseline seen with diet-only weight reduction, but emerging case evidence suggests resistance…
Calcium-to-magnesium ratio matters more than total calcium intake, research suggests
Research suggests calcium and magnesium function as physiological antagonists. Modern Western diets often exceed a 3:1 calcium-to-magnesium ratio, potentially increasing…
Health risks on African safari: Evidence-based prevention and management
Malaria, altitude sickness and travellers' diarrhoea are largely preventable. Medical advice 4–6 weeks before departure is essential.
Safari health: seven evidence-based questions to answer before an East African safari
Malaria, vaccinations, altitude and Tanzania's new mandatory travel insurance: a GMJ commentary with Africa Calling Safaris opens a weekly Safari…