Announcement: Single protein discovery could unlock CAR-T cell therapy’s full potential

Last updated: 13/06/2026 08:51

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Researchers identify NFIL3 protein as key barrier to CAR-T cell therapy success. Disabling this protein maintained stronger cancer-fighting activity in preclinical models. — Photo: turek / Pexels

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🧬 Breakthrough discovery: Single protein NFIL3 identified as major barrier to CAR-T cell therapy success. When disabled, engineered immune cells maintained cancer-fighting power longer in preclinical studies. This could transform cancer immunotherapy durability.

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GMJ Brief · Announcement

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ByProf. Giorgi Pkhakadze

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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.