New research quantifies the human toll of stigma on HIV prevention efforts in Zambia. A study of 262 sex workers in Lusaka found that 28.2% experienced high levels of chronic discrimination—and this stigma had measurable health consequences. Women reporting chronic discrimination were 65% more likely to discontinue HIV prevention medication (PrEP) within three months compared to those without such experiences. The prospective cohort conducted by UC San Francisco researchers tracked participants between July and October 2023, with electronic medical records documenting adherence patterns. Among early discontinuers, 32.2% reported high chronic discrimination versus 27.1% of those maintaining regular medication refills. The discrimination was primarily attributed to sex workers being identified based on their occupation. These findings underscore how social determinants of health directly impact biomedical prevention strategies, particularly among populations facing disproportionate HIV risk.
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