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GMJ News > GMJ Briefs > The Three-Stage Engine: How Your Cells Convert Food Into Energy

The Three-Stage Engine: How Your Cells Convert Food Into Energy

GMJ
Last updated: 04/10/2026 21:26
By
Prof. Giorgi Pkhakadze, MD, MPH, PhD
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1 Min Read
Diagram showing glycolysis, Krebs cycle, and electron transport chain energy production pathways in cells
Cellular energy production occurs through three metabolic stages: glycolysis, the Krebs cycle, and the electron transport chain, which generates approximately 90% of total ATP. Understanding this process reveals why lifestyle factors—including exercise, sleep, nutrition, and stress management—directly affect energy levels by enhancing mitochondrial function. — Photo by Rick Rothenberg on Unsplash (Unsplash License)
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1 min read|146 words

Energy production at the cellular level is far more complex than many realize. Your cells employ a three-stage metabolic process to convert glucose and nutrients into adenosine triphosphate (ATP), the universal currency of cellular energy. This process begins with glycolysis, a rapid cytoplasmic breakdown of glucose that provides quick but short-lived energy. The second stage, the Krebs cycle, continues the energy extraction process. The final and most efficient stage, the electron transport chain, accounts for approximately 90 percent of total ATP generation. Understanding these mechanisms explains why lifestyle choices—exercise, sleep quality, nutrition, and stress management—have such profound effects on your energy levels and cognitive performance. Rather than viewing fatigue as a single disease entity, researchers increasingly recognize it as a reflection of dysfunction in these fundamental cellular pathways. By supporting mitochondrial health through evidence-based lifestyle interventions, individuals can optimize their body’s natural energy production systems.

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ByProf. Giorgi Pkhakadze, MD, MPH, PhD
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MD, MPH, PhD. Editor-in-Chief, Georgian Medical Journal (GMJ). Professor and Head, School of Public Health, David Tvildiani Medical University (DTMU), Tbilisi, Georgia. Chair, Public Health Institute of Georgia (PHIG). President, Accréditation Sans Frontières (ASF), Paris. Secretary/Treasurer, UEMS Section of Public Health. WHO Consultant, Health and Migration, Geneva. Former Member, UN Secretary-General's Independent Accountability Panel for Every Woman, Every Child, Every Adolescent (IAP-EWEC, 2016–2021). ORCID: 0000-0001-7609-4515.

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