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Clinical updates, guidelines, prescribing, and practical medicine

Carbohydrate Ingestion During Endurance Exercise: Meta-Analysis Shows Modest Glycogen Sparing Effect

A meta-analysis of 31 crossover trials reveals that carbohydrate ingestion during prolonged endurance exercise reduces muscle glycogen depletion by approximately…

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Close Contact Alone May Not Drive Influenza Transmission, Controlled Study Suggests

A controlled human challenge–transmission study found that prolonged close contact with influenza-infected individuals did not reliably produce secondary infections, suggesting…

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Biogen-Denali Parkinson’s Drug Fails Phase 2 Trial, Highlighting Treatment Development Challenges

Biogen and Denali's experimental Parkinson's therapy failed Phase 2 trial endpoints, highlighting ongoing challenges in…

EU and US Drug Regulators Split Over AstraZeneca’s New Breast Cancer Treatment

European and American drug regulators reached opposing conclusions on AstraZeneca's experimental breast cancer treatment. The…

One Third of US Adults Don’t Get Recommended Sleep: Evidence-Based Guide to Sleep Optimization

New research reveals one-third of American adults don't achieve recommended sleep duration of 7-9 hours…

Five Key Mechanisms Drive Hypertension Beyond Simple Blood Pressure Numbers

New analysis reveals hypertension results from five distinct mechanisms rather than a single disease process.…

How the Brain Controls Testosterone Production Through Complex Feedback Systems

Testosterone production is controlled by a complex brain-gonad feedback system, not gym workouts. New research…