Tag: preclinical research
Amphibian bacterium eliminates colorectal tumors in mice with single dose — potential breakthrough for solid cancers
A bacterium from amphibian intestines completely eliminated colorectal tumors in mice with a single treatment by combining direct cancer cell…
Gene Therapy Restores Muscle Function in Nemaline Myopathy Type 6: New Hope for Rare Genetic Disorder
A new study published in Science Translational Medicine demonstrates that reducing Kbtbd13 gene expression restores muscle function in nemaline myopathy…
Experimental Drug DT-109 Reverses Severe Fatty Liver Disease by Repairing Gut Barrier in Animal Studies
An experimental compound called DT-109 reversed severe fatty liver disease in preclinical animal models by restoring intestinal barrier integrity and…
Engineered silica nanoparticles trigger prostate cancer cell death in mouse studies
Engineered silica nanoparticles triggered prostate cancer cell death and immune activation in preclinical mouse studies. Combined with immunotherapy, the treatment…
Neurotensin Receptor 2 Activation Shows Promise in Preventing Heart Failure Progression
Activation of neurotensin receptor 2 in preclinical models significantly reduced pathological changes in heart tissue, suggesting a novel therapeutic target…
Novel Prime-and-Pull Vaccine Strategy Shows Promise Against Genital Herpes in Preclinical Models
Yale researchers developed a novel prime-and-pull vaccine that prevented genital herpes infection in preclinical models, potentially addressing a 30-year gap…
Post-exercise brain signal may be key to fitness gains, mouse study suggests
Researchers at Jackson Laboratory and University of Pennsylvania identified brain neurons that appear necessary for endurance training to produce fitness…
Scientists Reprogram Brain Immune Cells to Combat Alzheimer’s Disease
Researchers have identified a molecule called OLE that restores protective function in brain immune cells in Alzheimer's disease models. The…