Prof. Giorgi Pkhakadze
How Creatine Supplements Reshape Your Body’s Methylation Cycle
Your body produces 2 grams of creatine daily, consuming 40% of your total methyl group supply. When you supplement creatine,…
Why vitamin D prescriptions favour weekly boluses over daily doses — and what the evidence says
Vitamin D prescriptions typically specify 50,000 IU weekly, a pattern driven by patient adherence rather than pharmacological advantage. A randomised…
Mitochondria as metabolic decision-makers: how cellular power plants regulate inflammation, aging, and disease
Mitochondria function as metabolic control centers that regulate inflammation, aging, and disease susceptibility across multiple organ systems through energy signaling…
How minerals shape brain function: what neuroscience reveals about micronutrient deficiency
Minerals are fundamental to brain function, regulating neurotransmission, neuroplasticity, and neuronal resilience. From iodine's role in cognitive development to lithium's…
Stress impairs memory and attention by up to 20%, study finds—but botanical interventions show promise
Acute psychological stress reduces memory and attention test performance by approximately 20%, according to research. Botanical compounds like Rhodiola and…
How the body metabolises alcohol: the biochemistry behind why drinks linger
Alcohol metabolism is a three-step enzymatic pathway that generates toxic acetaldehyde and depletes NAD⁺ cofactors, explaining why drinks linger in…
How glycine lowers core body temperature to trigger sleep—a thermostat mechanism
Glycine triggers sleep by lowering core body temperature through activation of the suprachiasmatic nucleus and peripheral vasodilation—the same thermoregulatory cascade…
How Creatine Actually Works: The ATP Shuttle System Explained
Creatine supplementation does not work primarily through water retention or caffeine-like stimulation. Instead, it enhances the phosphocreatine shuttle system, which…