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GMJ News > GMJ Briefs > Announcement: How a single dose of creatine protects cognitive function during sleep deprivation

Announcement: How a single dose of creatine protects cognitive function during sleep deprivation

GMJ
Last updated: 09/08/2026 03:30
By
Prof. Giorgi Pkhakadze
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Brain energy metabolism and phosphocreatine shuttle system diagram during sleep deprivation
A single high-dose oral creatine supplement preserved cognitive performance by up to 12% during severe sleep deprivation in a small randomised trial, suggesting that the brain's energy crisis during fatigue can be partially mitigated by exploiting acute metabolic shifts that enhance creatine uptake across the blood-brain barrier. — Photo by Slumber Sleep Aid on Unsplash (Unsplash License)
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1 min read|54 words

Your brain burns 20% of your body's energy at rest. Sleep deprivation drains its phosphocreatine buffer, tanking cognition. A team at Forschungszentrum Jülich found that a single 14g dose of creatine preserved performance by up to 12% during 21 hours without sleep—especially in women. Fascinating new mechanism.

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ByProf. Giorgi Pkhakadze
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Prof. Giorgi Pkhakadze, MD, MPH, PhD, is Editor-in-Chief of the Georgian Medical Journal and Chair of the Public Health Institute of Georgia (PHIG). He is Professor and Head of the Department of Social and Behavioural Sciences at David Tvildiani Medical University, and Secretary/Treasurer of the UEMS Section of Public Health. ORCID: 0000-0001-7609-4515.

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