Explainers

Plain-language deep dives for public audiences

Hypertension’s Hidden Complexity: Why One-Size-Fits-All Treatment Fails

Hypertension is not a single disease but a clinical manifestation of dysregulation across five distinct physiological systems: fluid retention, kidney…

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Georgia's peer-reviewed open-access medical journal. No APC until January 2027.

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How Your Body Makes and Uses Creatine: The Complete Energy System Explained

Creatine is a naturally occurring molecule synthesized in the kidneys and liver that serves as…

Brain Energy Demands: Why Your Hardest Thinking Uses Only 5% More Fuel

The brain uses only 5% more energy during intensive thinking than at rest, because baseline…

How Your Gut Absorbs Nutrients: A Section-by-Section Guide to Digestive Checkpoints

Nutrient absorption is not a single process but a carefully choreographed sequence distributed across seven…

How Vitamin D Becomes an Antimicrobial Weapon Inside Your Immune Cells

Macrophages actively convert vitamin D into cathelicidin, a potent antimicrobial peptide, when pathogens are detected.…

Brain’s Energy Demands: Why B Vitamins and Micronutrients Matter for Cognitive Function

The human brain consumes 20% of body energy in adults—rising to 50% in children around…

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