Published in: Georgian Medical Journal | Case Report | Vol. 1 No. 3 (2026)
Authors: Giorgi Tkeshelashvili
DOI: 10.66636/gmj.v1.i3.a193
Modern automated haematology analysers are fast, accurate — and sometimes wrong. A case report by Georgian haematologist Giorgi Tkeshelashvili, published in the Georgian Medical Journal, illustrates why human expertise still matters when machines give unexpected results.
The Case: Familial Pelger-Hüet Anomaly
Pelger-Hüet anomaly is a benign inherited condition affecting white blood cells, giving them an unusual appearance that can mimic more serious conditions such as left-shifted neutrophilia (a sign of severe infection) or myelodysplastic syndrome. Automated counters are particularly prone to misclassifying these cells.
The Lesson
This case demonstrates that when automated results don’t fit the clinical picture, a physician’s eye under the microscope remains irreplaceable. It’s a reminder that technology supports — but does not replace — clinical judgement.
Read the Full Case Report
📄 Read the full article in the Georgian Medical Journal
🔗 DOI: 10.66636/gmj.v1.i3.a193
📥 Download PDF
Published in: Georgian Medical Journal, Vol. 1 No. 3 (2026) — Surgical Innovation, Paediatrics, and Environmental Health
Open Access · CC BY 4.0 · ISSN 3088-4322
Original publication: The clinical significance of manual microscopy in resolving automated haematology discrepancies: a case study of familial Pelger-Hüet anomaly
Published in the Georgian Medical Journal (GMJ) — ISSN 3088-4322 — gmj.ge
Open Access under Creative Commons Attribution 4.0 International (CC BY 4.0)
Was this article helpful?
Disclaimer. This article is health journalism intended for general information and education. It is not medical advice and is not a substitute for professional diagnosis or treatment. Always consult a qualified healthcare provider about your individual circumstances. Full disclaimer →
Related Coverage
Editorial standards. This article was produced under the GMJ News editorial process, with oversight by the GMJ Editorial Board. Our editorial process. Spotted an error? Contact the editorial team.
