Published in: Georgian Medical Journal | Systematic Review | Vol. 1 No. 3 (2026)
Authors: Tamar Gaprindashvili, Rusudan Agladze, Zurab Pagava
DOI: 10.66636/gmj.v1.i3.a185
Anthracyclines are among the most effective chemotherapy agents available — but they carry a well-known risk of heart damage. A new review published in the Georgian Medical Journal explores a critical but underappreciated question: are patients with high blood pressure at disproportionately higher risk?
The Research Question
Georgian researchers Tamar Gaprindashvili, Rusudan Agladze, and Zurab Pagava propose that hypertensive cardiac remodelling — the structural changes the heart undergoes due to long-term high blood pressure — creates a specific vulnerability phenotype that makes anthracycline-induced heart damage more likely and more severe.
Imaging and Biomarkers as Early Warning Tools
The review examines how modern cardiac imaging and blood biomarkers could be used to identify high-risk patients before chemotherapy begins — potentially saving lives through earlier intervention and treatment modification.
Read the Full Study
📄 Read the full article in the Georgian Medical Journal
🔗 DOI: 10.66636/gmj.v1.i3.a185
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Published in: Georgian Medical Journal, Vol. 1 No. 3 (2026) — Surgical Innovation, Paediatrics, and Environmental Health
Open Access · CC BY 4.0 · ISSN 3088-4322
Original publication: Hypertensive remodelling as a testable myocardial vulnerability phenotype in anthracycline cardiotoxicity
Published in the Georgian Medical Journal (GMJ) — ISSN 3088-4322 — gmj.ge
Open Access under Creative Commons Attribution 4.0 International (CC BY 4.0)
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